Stent-Retriever Thrombectomy after Intravenous t-PA vs. t-PA Alone in Stroke

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Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke.

BACKGROUND Among patients with acute ischemic stroke due to occlusions in the proximal anterior intracranial circulation, less than 40% regain functional independence when treated with intravenous tissue plasminogen activator (t-PA) alone. Thrombectomy with the use of a stent retriever, in addition to intravenous t-PA, increases reperfusion rates and may improve long-term functional outcome. ...

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Endovascular therapy after intravenous t-PA versus t-PA alone for stroke.

BACKGROUND Endovascular therapy is increasingly used after the administration of intravenous tissue plasminogen activator (t-PA) for patients with moderate-to-severe acute ischemic stroke, but whether a combined approach is more effective than intravenous t-PA alone is uncertain. METHODS We randomly assigned eligible patients who had received intravenous t-PA within 3 hours after symptom onse...

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Stent-Retriever Thrombectomy for Stroke.

To the Editor: In their report on the Solitaire with the Intention for Thrombectomy as Primary Endovascular Treatment (SWIFT PRIME) trial, Saver et al. (June 11 issue)1 provide additional evidence on the effectiveness of endovascular therapy for acute ischemic stroke.2-5 In phase 3 stroke trials, the functional outcome on the modified Rankin scale is typically regarded as an important and valid...

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endovascular treatment of acute stroke due to cardiac myxoma. J Neurointerv Surg. 2012;6:e. 11. Jovin TG, Chamorro A, Cobo E, de Miquel MA, Molina CA, Rovira A, et al. Thrombectomy within 8 hours after symptom onset in ischemic stroke. N Engl J Med. 2015;372:2296—306. 12. Goyal M, Demchuk AM, Menon BK, Eesa M, Rempel JL, Thornton J, et al. Randomized assessment of rapid endovascular treatment o...

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Background: To determine whether it is possible to predict intravenous thrombolytic therapy (IVT) outcome after 3 months in acute ischemic stroke patients who are candidate to receive recombinant tissue plasminogen activator (rt-PA), before rt-PA administration based on their risk factors and some available laboratory results. Methods: We enrolled 118 ischemic stroke patients who were treated ...

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ژورنال

عنوان ژورنال: New England Journal of Medicine

سال: 2015

ISSN: 0028-4793,1533-4406

DOI: 10.1056/nejmoa1415061